Synthesis of some Schiff's bases derivatives from aminoazo compounds

Reaction of,2- [( 4- amio phenyl ) diazenyl] 1,3,4- thiadiazole -5- thiol (S1) with p- chlorobenzeldehyde,3,4 – dimethoxy benzaldehyde and pyrrol-2- carbonxaldehyde gave -5- [{4-(4-chlorobenzylidene amino) phenyl} diezenyl]-1,3,4- thiadiazole-2- thiol (S2),5-[{ 4-[(3,4- dimethoxybenzyldene )amino phenyl ] diazenyl)-1,3,4- thiadiazole-2-thiol,(S3) and -5- [4-(1,H – pyrrol -2- yl- methylene)amino phenyl] diazenyl)-1,3,4- thiadiazole-2- thiol (S4) respectively as schiff's bases compounds. On the same route-2-[(4-amino-1- naphthyl ) diazenyl] -1,3,4- thiadiazole -5- thiol (S5) reacts with –p- chloro benzaldehyde and –m- nitrobenzaldehyde to give the follwing schiff's bases -5-[{ 4-(4- chloro benzylidene ) amino -1- naphthyl} diazenyl] -1,3,4- thiadiazole -2- thiol (S6) and -5- ({ 4- [3- nitrobenzylidene) amino] -1- naphthyl({ diazenyl) -1,3,4 – thiadiazole-2- thiol (S7). Sn2 reaction was carried out by the reaction of compound (S6,S7) with bromo ethyl acetate to get ethyl[5{4-(4- chlorobenzylidene amino)-1- naphthyl} diazenyl] -1- 1,3,4- thiadiazole-2- yl- thio] acetate (S8) and ethyl [5-{4- (2- nitrobenzylidene amino)-1- naphthyl diazenyl] -1,3,4- thiadiazole -2-yl-acetate (S9).(Fig.1)

Respiratory Motion Correction on 3D Positron Emission Tomography Images

PET/CT Gräte erlauben gleichzeitige morphologische und anatomische Bildaufnahme des Körpers. Die Aufnahmemodalitäten bedingen, dass bei der Positronen-Emissions-Tomographie (PET) der Patient weiter Atmet. Bei der Computer Tomographie (CT) dagegen, die nur wenige Sekunden dauert, hält er seinen Atem. Aufgrund der Diskrepanz zwischen den Aufnahmen kommt es zu Artefakten bei der Gewichtung der PET-Daten durch die CT-Daten. Diese Gewichtung ist aber für Quantitative PET-Daten notwendig. Des Weiteren können kleine Tumore durch die Verschmierung der Daten im Rauschen untergehen. In dieser Arbeit wird eine Lösung des Problems vorgeschlagen die auf zwei Schritte beruht. Zunächst werden die PET-Daten in verschiedene Atemphasen unterteilt. Im zweiten Schritt werden die Daten verschiedener Phasen mit einer Zielphase in Übereinstimmung gebracht. Hierzu wird eine Optical Flow Methode benutzt. Die Ergebnisse auf Phantom und auf Patientendaten zeigen, dass das Problem erfolgreich gelöst worden ist

PHYTOCHEMICAL SCREENING, ANTIOXIDANT PROPERTIES IN VARIOUS EXTRACTS FROM THE LEAVES OF FLAGELLARIA INDICA L. FROM SABAH, MALAYSIA

Objective: This study was conducted to evaluate the antioxidant capacities of the leaves of Flagellaria indica L. (FI) and its phytochemical constituents in six different extracts.Methods: The assessment was done via a 2,2-diphenyl-1-picryl hydrazyl (DPPH) radical scavenging assay for the antioxidant test, the Folin-ciocalteau method for total phenolic content, Willet's method for total flavonoid content and several other qualitative phytochemical tests carried out on all extracts.Results: The results show the highest values of radical scavenging in the following order of extracts: butanol>ethyl acetate>aqueous>chloroform>methanol>hexane. The total phenolic content is the highest in the ethyl acetate (e. acetate) extract (153.28 mg/g) followed by butanol (134.78 mg/g), aqueous extract (65.88 mg/g), chloroform (55.28 mg/g), methanol (45.98 mg/g) and hexane (22.78 mg/g), expressed as gallic acid equivalents. The total flavonoids content was also the highest in e. acetate extract (38.96 mg/g) followed by butanol (28.45 mg/g), aqueous (21.18 mg/g), chloroform (12.9 mg/g), methanol (10.78 mg/g) and hexane extract (4.92 mg/g) using cathechin equivalents.Conclusion: The antioxidant and radical scavenging activities of FI might be due to the strong presence of phenolic constituents, flavonoids and several other bioactive compounds. Thus, further research can be conducted to elucidate the potential of this plant for pharmacological importance.Â

The Impact of Using heat Insulation in Reducing Operational Energy and LCA Emission in Local Building,

The Building sector is one of the biggest sector in energy consumption and greenhouse gases emission, and the biggest phase of building life cycle that responsible of that consumption of energy and emission is operation phase (specially Heating and cooling) and it’s effected directly by building material thermal conductivity. There is a different ways to reduce operation consumption of energy and life cycle emission like using insulated wall and glazing. So the research problem will be “the need of applied research that compare the energy consumption of energy and emissions change in masonry building when using different thermal performance skins”. So the goal of the research is “measure and compare Building energy consumption in operation phase and emissions in life cycle of Masonry Building”. The conclusion of this research is that the possibility to reduce energy used in building to 44.8% and reducing emission to 56.4% using cavity wall and insulation in Masonry Building. Assessed by Life Cycle Assessment method. Key Words: Emissions, Life Cycle Assessment (LCA), Project Management – Environmental Management

Biopiracy <i>versus </i>one-world medicine – from colonial relicts to global collaborative concepts

Background: Practices of biopiracy to use genetic resources and indigenous knowledge by Western companies without benefit-sharing of those, who generated the traditional knowledge, can be understood as form of neocolonialism.Hypothesis: : The One-World Medicine concept attempts to merge the best of traditional medicine from developing countries and conventional Western medicine for the sake of patients around the globe.Study design: Based on literature searches in several databases, a concept paper has been written. Legislative initiatives of the United Nations culminated in the Nagoya protocol aim to protect traditional knowledge and regulate benefit-sharing with indigenous communities. The European community adopted the Nagoya protocol, and the corresponding regulations will be implemented into national legislation among the member states. Despite pleasing progress, infrastructural problems of the health care systems in developing countries still remain. Current approaches to secure primary health care offer only fragmentary solutions at best. Conventional medicine from industrialized countries cannot be afforded by the impoverished population in the Third World. Confronted with exploding costs, even health systems in Western countries are endangered to burst. Complementary and alternative medicine (CAM) is popular among the general public in industrialized countries, although the efficacy is not sufficiently proven according to the standards of evidence-based medicine. CAM is often available without prescription as over-the-counter products with non-calculated risks concerning erroneous self-medication and safety/toxicity issues. The concept of integrative medicine attempts to combine holistic CAM approaches with evidence-based principles of conventional medicine.Conclusion: To realize the concept of One-World Medicine, a number of standards have to be set to assure safety, efficacy and applicability of traditional medicine, e.g. sustainable production and quality control of herbal products, performance of placebo-controlled, double-blind, randomized clinical trials, phytovigilance, as well as education of health professionals and patients

Tourists’ Perceptions of Insects as the Determinants of Insect Conservation through Entomological Ecotourism

Insects are commonly featured in recreation and tourism around the world, despite the generally negative public perception surrounding them. Many people enjoy watching butterflies in insectarium gardens, observing and collecting dragonflies, and admiring the light displays of fireflies. In many cases, activities like these are becoming increasingly popular and these positive interactions with insects encourage public appreciation of insects, but vary acuities in their forms and approaches. Thus, understanding the pattern of insect appearances in recreation and tourism activities in a variety of discernments can provide important insights into effective ways of promoting insect conservation through ecotourism, which is often overlooked in biodiversity conservation strategies. However, these types of interdisciplinary studies are relatively new and remain limited in both entomology and tourism sciences. A field survey was carried out at Kangkawat Research Station, Imbak Canyon Conservation Area, where a 1 kilometre entomological ecotourism trail was designed and developed to incorporate insects in enhancing ecotourism at the reserve. Insects that can be found along the 1 kilometre trail were recorded and the collection was conducted using baited traps and sweep netting. Based on the insects survey, the Shannon Diversity Index (H’) of Kangkawat is 4.60 while Simpson Index is 176.72 with Fisher Alpha Index at 313.3 that concludes Kangkawat Research Station insect richness to be the second highest after the Crocker Range. In adressing the knowledge gaps between insect conservation and ecotourism, a survey on attitudes towards insects was designed and then completed by 384 tourists around Kota Kinabalu City. The standardized questionnaire known as the Personal Meaning of Insects Map (PMIM) was administered to tourists and their responses were elicited prior to and after observing insect photos. The results shows that “spider” had the 100% connectivity in response to the most detested insect based on their previous encounters with insects. This result shows that there is an existing entomology knowledge gap among the respondents, indicating the need for further interventions in terms of nature interpretation. Therefore a quality guided nature interpretation as an educational tool should take into account how the general public understands (or misunderstands) insects further and where interpretive information could be better applied if we are to develop management and educational tools that address human-insect encounters

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Global economic burden of unmet surgical need for appendicitis

Background: There is a substantial gap in provision of adequate surgical care in many low-and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods: Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results: Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US $92 492 million using approach 1 and$73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was $95 004 million using approach 1 and$75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion: For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially

CoNIC Challenge: Pushing the Frontiers of Nuclear Detection, Segmentation, Classification and Counting

Nuclear detection, segmentation and morphometric profiling are essential in helping us further understand the relationship between histology and patient outcome. To drive innovation in this area, we setup a community-wide challenge using the largest available dataset of its kind to assess nuclear segmentation and cellular composition. Our challenge, named CoNIC, stimulated the development of reproducible algorithms for cellular recognition with real-time result inspection on public leaderboards. We conducted an extensive post-challenge analysis based on the top-performing models using 1,658 whole-slide images of colon tissue. With around 700 million detected nuclei per model, associated features were used for dysplasia grading and survival analysis, where we demonstrated that the challenge's improvement over the previous state-of-the-art led to significant boosts in downstream performance. Our findings also suggest that eosinophils and neutrophils play an important role in the tumour microevironment. We release challenge models and WSI-level results to foster the development of further methods for biomarker discovery

Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.

Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. The primary outcome was the rate of AKI within 7 days of surgery. Bootstrap stability was used to select clinically plausible risk factors into the model. Internal model validation was carried out by bootstrap validation. Results: A total of 4544 patients were included across 173 centres in the UK and Ireland. The overall rate of AKI was 14·2 per cent (646 of 4544) and the 30-day mortality rate was 1·8 per cent (84 of 4544). Stage 1 AKI was significantly associated with 30-day mortality (unadjusted odds ratio 7·61, 95 per cent c.i. 4·49 to 12·90; P < 0·001), with increasing odds of death with each AKI stage. Six variables were selected for inclusion in the prognostic model: age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. Internal validation demonstrated good model discrimination (c-statistic 0·65). Discussion: Following major gastrointestinal surgery, AKI occurred in one in seven patients. This preoperative prognostic model identified patients at high risk of postoperative AKI. Validation in an independent data set is required to ensure generalizability